This review discusses the interaction and mechanisms between autophagy and circadian rhythm. In addition, autophagy can affect circadian rhythm by degrading circadian proteins. Recent studies have indicated that autophagy is activated rhythmically in a clock-dependent manner whether the organism is healthy or has certain diseases. The factors affecting autophagy are numerous, such as diet, drugs, and aging. Autophagy is a conserved biological process contributing to nutrient and cellular homeostasis. The most essential physiological functions of mammals are manifested in circadian rhythm patterns, including the sleep-wake cycle and nutrient and energy metabolism.
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